Tsunade

Tsunade is a descendant of the Senju and Uzumaki Clan, and is one of the Hidden Leaf’s Legendary Sannin. She is famed as the world's strongest kunoichi and is able to perform the greatest medical-ninjutsu. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years. She is eventually persuaded to return to Konoha and take on the mantle of Fifth Hokage