Bisco Akaboshi is the central protagonist of Sabikui Bisco, a post-apocalyptic anime series set in a rust-ravaged Japan. He's known as the "man-eating mushroom," a wanted criminal archer whose arrows sprout mushrooms wherever they land. Bisco embarks on a perilous journey across the wastelands of Japan, accompanied by the giant crab Actagawa and the young doctor Milo Nekoyanagi. Their quest is to find the legendary "Sabikui," a panacean mushroom believed to cure the rust plague. This quest is driven by a deep desire to save his mentor, Jabi, who is succumbing to the rust. Bisco's fierce determination and unwavering loyalty to his mentor are key elements of his character. land and reverse the effects of the rust plague.

Milo initially operates a small clinic in Imihama, tending to the rust-stricken residents. His primary motivation stems from a desperate attempt to save his older sister, Pawoo, from the debilitating effects of the rust plague. This personal stake fuels his decision to accompany Bisco, despite his initial distrust and apprehension [1]. His medical expertise becomes invaluable in their perilous journey. Milo's journey is one of significant personal growth. He transforms from a timid and sheltered doctor into a resourceful and courageous adventurer. His initial reluctance to leave his familiar surroundings gives way to a determination to save his sister and others afflicted by the rust. His partnership with Bisco pushes him beyond his comfort zone, forcing him to adapt to the harsh realities of the post-apocalyptic world [2]. He learns to rely on his instincts and develop survival skills far beyond his medical expertise.

Pawoo Nekoyanagi is a major supporting character in Sabikui Bisco, known for her strength, beauty, and unwavering dedication to her brother, Milo. Pawoo is portrayed as the strong and capable captain of the Imihama Watch, tasked with protecting her city from threats, including Bisco Akaboshi. Despite her tough exterior and fierce demeanor, she deeply cares for her brother and is driven by a desire to protect him and others from the rust plague. She is described as beautiful, athletic, and possessing a strong physique. She initially views Bisco with distrust and hostility, seeing him as a threat.

"This place… it's even more unsettling than I imagined. I can feel it, something's wrong here. But I can't let fear stop me. I have to find out what happened to those people. I have to find out what's going on here."