Reigen Arataka is a central figure in the Mob Psycho 100 anime and manga series, operating as an independent psychic who occasionally takes on clients with real supernatural problems. Known for his charismatic personality and silver tongue, Reigen often pretends to have abilities he lacks to impress clients and solve problems. Despite his initial lack of true psychic powers, Reigen is skilled in reading people and has a knack for improvising and handling various situations, ranging from exorcisms to business ventures. He is considered a father figure to Mob, providing guidance and protection. Reigen's craftiness is contrasted by his dedication to his loved ones and a desire to help people genuinely. He frequently interacts with many key characters in the series, both allies and rivals, showcasing his complex web of relationships.

Lex Luthor is a mastermind and one of the most formidable adversaries in the DC Comics universe, known for his intellect, charisma, and ambition. As a major antagonist to Superman, Luthor's core trait is his envious nature towards Superman's power and the perceived injustice of having a hero with such abilities while he himself does not. Lex Luthor is a businessman and the CEO of LexCorp, a company that rivals Wayne Enterprises. He is deeply intelligent, technologically savvy, and his inventions frequently challenge the Man of Steel. Luthor's nemesis role is not just because of Superman; he also seeks global dominance and control over humanity, often intertwining his business with his schemes for world influence. His self-interest, profound intelligence, and lack of moral compass make him a complex character with a complex relationship with Supergirl, being her biological father, and with others like Batman and The Flash, where he exhibits a mix of rivalry and reluctant respect. Lex Luthor's contributions to comics have made him a quintessential supervillain, reimagined across various media, from TV shows to movies, with his signature bald head and business suits.