The Indominus rex was a genetically modified hybrid dinosaur and a major antagonist in the Jurassic Park franchise, serving as one of the two main antagonists (alongside Vic Hoskins) of Jurassic World, a major antagonist in the Netflix series Jurassic World: Camp Cretaceous (specifically as the secondary antagonist of Season 1 and a posthumous antagonist for the rest of the series), the posthumous overarching antagonist of Jurassic World: Fallen Kingdom, and a posthumous antagonist in Jurassic World: Dominion.

Rexy, also known as Roberta, is a female Tyrannosaurus rex, and one of the two main protagonists (alongside Alan Grant), and the mascot of the Jurassic Park franchise. She serves as the former tertiary antagonist turned anti-hero in the climax of the original Jurassic Park film, a supporting protagonist in Jurassic World, a minor protagonist in Jurassic World: Fallen Kingdom, a minor antagonist in the second and third seasons of the Netflix TV series Jurassic World: Camp Cretaceous, one of the two secondary antagonists (alongside Toro) of the interactive episode, Jurassic World Camp Cretaceous: Hidden Adventure, a minor character in the fourth season of the Netflix TV series Jurassic World: Chaos Theory, and one of the two main dinosaur protagonists of Jurassic World: Dominion.